SYMPOSIA
THE PLACE OF EEG IN DRUG DEVELOPMENT

25 - 26 - 27 September 2008

THURSDAY 25th SEPTEMBER 2008
08:00 - 09:00 Registration Symposium
09:00 - 09:30 Opening of Symposium
Ruigt Gé (IPEG President), Luthringer R (CEO, FORENAP), Wesner P (Director, Rouffach Hospital), Carboni N (General Manager, BioValley)
09:30 - 11:00 Session 1 - The place of EEG studies in animals
Chair : Drinkenburg P (Johnson&Johnson, Belgium) & Ruigt Ge (NV Organon, The Netherlands)

Pharmacological characterization of the sleep-wake effects of the antidepressant mirtazapine (by Ward N, Schering-Plough, Scotland)
Quantitative pharmaco-electroencephalography in drug discovery: an old friend revisited (by Ahnaou A, Johnson&Johnson, Belgium)
Disturbed sleep in MPTP induced parkinsonian marmoset monkeys (by Philippens I, BPRC, The Netherlands)
GABAA a2 subunits and EEG modulations in the behaving rat: distinct and translational interactions (By Christian E, AstraZeneca, USA)

11:00 - 11:30 Coffe break
11:30 - 13:00 Session 2 - Applications of q-EEG to drug evaluation in neurology
Chair: Hirata K (Dokkyo Medical University) & Pascual-Marqui RD (KEY Institute for Brain-Mind Research, Switzerland)

 Mood disturbance and Nogo-ERPs in Parkinson's disease (PD) (by Osawa M, Tokyo Women’s Medical University, Japan)
Cholinergic systems and cortical rhythms in Alzheimer disease: new findings (by Babiloni C, University of Foggia and IRCCS San Raffaele Pisana, Italy)
sLORETA-based age dependent norms of “default mode” electric neuronal activity: validation in acute cerebral infarction confirmed by SPECT and MRI (by Pascual-Marqui RD, KEY Institute for Brain-Mind Research, Switzerland)
Decrease in propagation of interictal epileptiform activity after introduction of levetiracetam, visualized with electric source imaging (by Lantz G, Functional Brain Mapping Laboratory, Switzerland)

13:00 - 14:00 Lunch
General Assembly Meeting 
14:00 - 15:30

Session 3- Application of q-EEG to drug evaluation in psychiatry
Chair: Saletu B (Medical University of Vienna, Austria) & Koenig T (University Hospital of Psychiatry, Switzerland)

Polysomnography and q-EEG studies in young and elderly normal subjects under first- and second-generation antipsychotics (by Saletu B, Medical University of Vienna, Austria)
Frontal qEEG-guided antidepressant selection may improve response and remission rates: insights from the BRITE-MD trial (by Cook IA, UCLA Semel Institute for Neuroscience and Human Behavior, USA)
EEG synchronization in untreated schizophrenia (by Koenig T, University Hospital of Psychiatry, Switzerland)
Treatment effects on resting state EEG in schizophrenia (by Kikuchi M, Kanazawa University, Japan)

15:30 - 16:00 Coffee break
16:00 - 17:30

Session 4- Sleep EEG in translational research from neuroscience to clinical psychiatry
Chair: Steiger A (Max Planck Institute of Psychiatry, Germany) & Holsboer-Trachsler E (Psychiatric University Clinics Basel, Switzerland)

Sleep-EEG characteristics of antidepressants in the mouse model (by Kimura M, Max Planck Institute of Psychiatry, Germany )
Sleep-EEG and antidepressant treatment: short-term outcome and long-term course (by Hartzinger M, University Hospital of Basel, Switzerland)
Pharmacological challenges during sleep deprivation in depression (by Holsboer-Trachsler E, Psychiatric University Clinics Basel, Switzerland)
Effects of peptides on human sleep EEG (by Steiger A, Max Planck Institute of Psychiatry, Germany)
Effects of cholinesterase inhibitors on sleep EEG in dementia (by Hemmeter U, Cantonal Psychiatric Hospital, Switzerland)

17:30 - 18:00 Plenary lecture (by Wesnes K, CDR Ltd, UK)
Does integrating cognitive function testing and electroencephalography produce more than the sum of the parts?
18:00 - 19:00 Poster Session


FRIDAY 26th SEPTEMBER 2008
08:30 - 10:00

Session 5- Relevance of pharmaco-EEG : a debate between academia and industry
Chair: Spedding M (Institute of Research Servier, France) & van Rijn CM (Institute for Brain and Cognition, The Netherlands)
Interactive session with active participation of the audience

Open discussion paper: Absence-status epilepticus caused by cannabinoids? (by van Rijn CM, Institute for Brain and Cognition, The Netherlands)
Theta band LFP coherence between hippocampus and prefrontal cortex and reorganization of ensemble cell activity during learning (by Wiener S, Collège de France, France)
Stress : a neural disconnection syndrome – can electrophysiology rescue drug discovery? (by Spedding M, Institute of Research Servier, France)

10:00 - 10:30 Coffe break
10:30 - 12:00

Session 6 – EEG-based personalized Medecine
Chair:  Arns M (Brainclinics Diagnostics, The Netherlands) & Hoffman D (CNS Response, Inc, USA)

EEG phenotypes predict treatment outcome to stimulants in children with ADHD (by Arns M, Brainclinics Diagnostics, The Netherlands)
EEG susceptibility markers in personalized medicine for depression and ADHD (by Barnett K, Brain Resource Company, Australia)
Referenced-EEG (rEEG) guided medication selection for psychotropics (by Hoffman D, CNS Response, Inc. and Neuro-Therapy Clinic, Inc, USA)
Pre-and post-qEEG, ERP and behavioral effects of left frontal magnetic stimulation (rTMS) in depression: implications for personalized medicine (by Spronk D, Brainclinics Diagnostics, The Netherlands)

12:00 - 13:15 Lunch
13:15 - 14:00

Plenary lecture (by Vollenweider FX, University Hospital of Psychiatry, Switzerland)
Brain mechanisms of serotonergic hallucinogens

14:00 - 15:30

Session 7- EEG studies in the ketamine / NMDA model of cognitive impairments and schizophrenia
Chair : Boeijinga P (FORENAP, France) & Oranje B

The effect of ketamine and haloperidol on human selective attention (by Oranje B, Glostrup, Denmark)
Effect of clozapine and ketanserin pretreatment on S-ketamine-induced symptoms and brain activation in healthy humans (by Vollenweider FX, University Hospital of Psychiatry, Switzerland)
NMDAr antagonists induce persistent abnormal gamma oscillations: behavioral, network and cellular features (by Pinault D, INSERM U666, France)
Effect of NMDA receptor antagonist memantine on mismatch negativity (by Korostenskaja M, CCHMC, USA)
Panel discussion

15:30 - 16:00 Coffee break
16:00 - 17:45 Oral communications

Sebban C, Debouzy C, Nguyen-Michel VH (France) A regression approach of inter EEG signals coherence - method and usefulness
Wester AE, Böcker KBE, Verster JC, Volkerts ER & Kenemans JL (The Netherlands) Dose-response effects of alcohol on lane keeping and P3A amplitude during simulated driving
Wix R, Meilán ml, Martínez-Chacón ML, de Dios E, Sola RG, Pastor J (Spain) etomidate activates irritative areas in patients with temporal lobe epilepsy
Barbanoj M, Romero S, Antonijoan R , Riba J (Spain) Mean lobe intracortical distribution of electrical activity after benzodiazepine intake: a dose-range study
Sürmeli T (Turkey) QEEG- Neurometric analysis guided neurofeedback (NF) treatment in medicated schizophrenia patients.Case study: 53 Patients  

17:45 - 18:45

Presentation of the last 2 IPEG Guidelines

Sleep analysis including first results with the new AASM standards for scoring sleep (by Anderer P, Medical University of Vienna, Austria)
The use of q-EEG results (by Luthringer R, FORENAP, France)
20:00 Gala


SATURDAY 27th SEPTEMBER 2008
08:30 - 10:00

Session 8- Complementary techniques applied to drug-neurophysiological research in healthy volunteers
Chair: Barbanoj M (Hospital de la SCI San Pau, Spain), Babiloni F (University of Rome “Sapienza”, Italy)

EEG-LORETA and SPECT: troubles on cross-modality correspondence (by Barbanoj MJ, Hospital de la SCI Sant Pau, Spain)
The estimation of cortical connectivity from high-resolution EEG measurements (by Babiloni F, University of Rome "Sapienza", Italy)
Complementary techniques applied to drug-neurophysiological research: event related potentials and functional magnetic resonance imaging (by Riba J, Hospital de la SCI Sant Pau, Spain)
Complementary techniques applied to drug-neurophysiological research: population pharmacokinetic/pharmacodynamic modeling (by Valle M, Hospital de la SCI Sant Pau, Spain)

10:00 - 10:30 Coffe break
10:30 - 12:15 Oral communications

Brunovsky M, Horacek J, Tislerova B, Sos P, Novak T, Krajca V (Czech Republic) Effects of subanesthetic dose of ketamine on the brain activity in model of schizophrenia: a standardized low-resolution brain electromagnetic tomography (s-LORETA) study
Pflueger MO, Gschwandtner U, Zimmermann R, Schindler C, Riecher A, Fuhr P (Switzerland) Spectral power density in the early course of schizophrenia
Gschwandtner U, Pflueger  M.O, Gaggiotti  M, Riecher A, Fuhr P (Switzerland) EEG in the detection of the beginning psychosis
Zimmermann R, Gschwandtner U, Pflueger M.O, Riecher A, Fuhr P (Switzerland) QEEG parameters as indicator for negative symptoms in patients with first episode schizophrenia

12:30 Closing remarks + snack