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ELECTROENCEPHALOGRAPHY
EEG multi-electrode mapping and event-related potentials (ERPs)
To evaluate the effect of new compounds on the CNS
Quantitative analysis of EEG modifications induced by psychoactive drugs (pharmaco-EEG) and statistical mapping techniques are used in our facilities as early as in phase I studies in order to highlight the central effect of a new compound. Several effects are routinely quantified: dose/response relationships, onset/duration, prediction of efficacy, CNS bioavailability, equivalence between 2 compounds and e.g. effects on vigilance.
New substances can also be compared with established reference drugs in terms of pharmaco-EEG profiles obtained in “resting” eyes closed (and/or open) conditions or with slight constraints under “vigilance controlled” conditions, carried out to support/recommend a (new) therapeutic indication even in healthy volunteers.Event-related potentials (pharmaco-ERP) induced by auditory or visual stimuli can be recorded and are a supplementary technique for the assessment of a functional profile of the molecule.
To accelerate the process for the assessment of putative therapeutic efficacy for a new substance, EEG surrogate markers can be studied using disease models in healthy volunteers (e.g., drug-induced schizophrenic-like symptoms, drug-induced aging-related impairments).
