A CRO with A unique CNS expertise

The research programs conducted by Forenap aiming to explore the various physiological functions of the central and peripheral nervous system, led to valuable expertise in the following fields:

Emotional states

Experimental psychology of basic emotions and links with pathological biases or biases induced by pharmacological manipulations
Techniques used: facial emotions recognition, mood induction by movies, mood scales, clinical scales

Vigilance states

Normal and pathological fluctuations, sleep deprivation, psychopharmacological manipulations
Techniques used: EEG mapping, quantitative EEG, evoked potentials, driving simulator, body sway, psychomotor coordination, psychomotor and neurocognitive tests

Pain

Evaluation of nociceptive phenomena and integration as perceived pain or medullar reflex
Techniques used: thermal and mechanical pain, capsaïcin + heat model, UV erythema + heat model, RIII reflex, cold pressor test, GTN-induced migraine model; subjective reading or pain matrix activation in neuroimaging

Cognitive functions

Learning, cognition, memory, aging, attention, executive functions
Techniques used: EEG mapping, quantitative EEG, imaging, fMRI, evoked potentials, psychomotor and neurocognitive tests, aging models, driving simulator

Psychiatric diseases

Bipolar disease, schizophrenia, anxiety disorders, depression
Techniques used: self rated scales and clinician-administered scales polysomnography, neuroendocrine tests, fMRI, quantitative EEG, human models

Psychopharmacology

Pharmacodynamics, Pharmacokinetics, drug interactions, PK/PD relationships, time effect (onset, offset), dose effects, biomarkers, human models
Techniques used: see previous headings ; NONMEM , SAS

Sleep

Normal and pathological sleep (insomnia, depression, periodic leg movements), sleep deprivation studies (partial and total), and sleep psychopharmacology.
Techniques used: EEG mapping, spectral analysis (EEG and ECG), periodic legs movements and apnea detection, insomnia models

Phenotyping, genotyping and individual profile (endophenotype)